Systemic Lupus erythematosus

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Characterisation of choroid plexus-infiltrating T cells reveals novel therapeutic targets in murine neuropsychiatric lupus

Erica Moore, Sushma Bharrhan, Deepak A Rao, Fernando Macian, Chaim Putterman

26 March 2024

Risk of flare and damage accrual after tapering glucocorticoids in modified serologically active clinically quiescent patients with systemic lupus erythematosus: a multinational observational cohort study

Yasuhiro Katsumata, Eisuke Inoue, Masayoshi Harigai, Jiacai Cho, Worawit Louthrenoo, Alberta Hoi, Vera Golder, Chak Sing Lau, Aisha Lateef, Yi-Hsing Chen, Shue-Fen Luo, Yeong-Jian Jan Wu, Laniyati Hamijoyo, Zhanguo Li, Sargunan SockalingamSee the full list of authors

29 February 2024

Haematopoietic stem cell-derived immune cells have reduced X chromosome inactivation skewing in systemic lupus erythematosus

Amy L Roberts, Alessandro Morea, Ariella Amar, Magdalena West, Sarah Karrar, Rhiannon Lehane, Philip Tombleson, Deborah Cunningham Grahman, John A Reynolds, Chloe C Y Wong, David L Morris, Kerrin S Small, Timothy J Vyse

27 June 2024

Molecular characterisation of lupus low disease activity state (LLDAS) and DORIS remission by whole-blood transcriptome-based pathways in a pan-European systemic lupus erythematosus cohort

Ioannis Parodis, Julius Lindblom, Guillermo Barturen, Rafaela Ortega-Castro, Ricard Cervera, Jacques-Olivier Pers, Fernanda Genre, Falk Hiepe, Maria Gerosa, László Kovács, Ellen De Langhe, Silvia Piantoni, Georg Stummvoll, Carlos Vasconcelos, Barbara VigoneSee the full list of authors

19 February 2024

Disease activity drives divergent epigenetic and transcriptomic reprogramming of monocyte subpopulations in systemic lupus erythematosus

Anna Guiomar Ferreté-Bonastre, Mónica Martínez-Gallo, Octavio Morante-Palacios, Celia Lourdes Calvillo, Josep Calafell-Segura, Javier Rodríguez-Ubreva, Manel Esteller, Josefina Cortés-Hernández, Esteban Ballestar

27 February 2024

Pragmatic targets for moderate/severe SLE and their implications for clinical care and trial design: sustained DORIS or LLDAS for at least 6 months is sufficient while their attainment for at least 24 months ensures high specificity for damage-free progression

Sofia Pitsigavdaki, Myrto Nikoloudaki, Panagiotis Garantziotis, Ettore Silvagni, Argyro Repa, Antonio Marangoni, Irini Flouri, Nestor Avgoustidis, Konstantinos Parperis, Antonis Fanouriakis, Marcello Govoni, Prodromos Sidiropoulos, Dimitrios T Boumpas, Alessandra Bortoluzzi, George Bertsias

17 January 2024

Telitacicept in patients with active systemic lupus erythematosus: results of a phase 2b, randomised, double-blind, placebo-controlled trial

Di Wu, Jing Li, Dong Xu, Joan T Merrill, Ronald F van Vollenhoven, Yi Liu, Jiankang Hu, Yang Li, Fen Li, Chenghui Huang, Guochun Wang, Xiaomei Li, Jianhong Zhao, Dongbao Zhao, Cibo HuangSee the full list of authors

21 December 2023

KLF2 enhancer variant rs4808485 increases lupus risk by modulating inflammasome machinery and cellular homoeostasis

Manish Kumar Singh, Harikrishna Reddy Rallabandi, Xu-Jie Zhou, Yuan-Yuan Qi, Zhan-Zheng Zhao, Ting Gan, Hong Zhang, Loren L Looger, Swapan K Nath

19 February 2024

Interleukin 4-driven reversal of self-reactive B cell anergy contributes to the pathogenesis of systemic lupus erythematosus

Yaoyang Liu, Zhiguo Zhang, Zijian Kang, Xu-jie Zhou, Shujun Liu, Shicheng Guo, Qianmei Jin, Ting Li, Ling Zhou, Xin Wu, Yan-na Wang, Liangjing Lu, Yanran He, Fubin Li, Hong ZhangSee the full list of authors

11 August 2023

Longitudinal gut microbiome analyses and blooms of pathogenic strains during lupus disease flares

Doua F Azzouz, Ze Chen, Peter M Izmirly, Lea Ann Chen, Zhi Li, Chongda Zhang, David Mieles, Kate Trujillo, Adriana Heguy, Alejandro Pironti, Greg G Putzel, Dominik Schwudke, David Fenyo, Jill P Buyon, Alexander V AlekseyenkoSee the full list of authors

26 June 2023

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